How Does 5-MTHF Fit into SleepWell? Formula & Label Guide
5-MTHF is 5-methyltetrahydrofolate, a methylated form of folate involved in one-carbon metabolism and the methionine/SAM network. SAM supplies a methyl group during the final enzyme step from N-acetylserotonin to melatonin. This pathway context does not show that 5-MTHF or SleepWell increases serotonin or melatonin, and it does not establish a sleep outcome.
Current formula context
- L-tryptophan — 500 mg
- Griffonia simplicifolia extract — 167 mg, standardized to 30% 5-HTP (approximately 50 mg; the current product page declares 50 mg 5-HTP)
- Magnesium — 160 mg as bisglycinate
- Zinc — 10 mg as citrate
- Vitamin B6 — 10 mg as P-5-P
- Vitamin D3 — 5 µg
- Folate — 400 µg as 5-MTHF
- Black pepper fruit extract — 4 mg, standardized to 95% piperine
What this video covers
- How 5-MTHF fits into one-carbon metabolism and the methionine/SAM network
- How L-tryptophan and 5-HTP sit at different points upstream of serotonin
- How to read source or form, declared amount, and the complete serving
- Why ingredient and enzyme studies do not test the finished SleepWell formula
- Which shared nutrients and botanicals to check across your routine
Video chapters
- 00:00 SleepWell’s melatonin-free evening formula
- 00:25 5-MTHF, one-carbon metabolism, and SAM
- 00:49 Complete two-capsule formula and exact amounts
- 01:36 Evening directions and safety warnings
- 02:14 Targeted purpose and ingredient overlap checks
Research and educational sources
- The source set includes the current BioEssentials product page and official composition image; primary human studies of 5-MTHF pharmacokinetics, low-dose 5-MTHF and homocysteine, and measured one-carbon metabolites; and biochemical studies of the SAM-dependent final step in melatonin synthesis. These studies did not test SleepWell and do not establish that the finished formula changes sleep, serotonin, or melatonin. Full citations and study boundaries are in the evidence guide above.
Important information
Take 2 capsules in the evening with water. Do not exceed the recommended daily dose. Intended for adults. May cause drowsiness; do not drive or operate machinery after use. Consult a healthcare professional before use during pregnancy or breastfeeding, with a health condition, or when taking medication—especially an antidepressant or other serotonergic medication. When combining food supplements, check total daily intake of shared vitamins, minerals and botanical ingredients. Keep out of reach of children. Food supplements should not replace a varied, balanced diet and a healthy lifestyle.
Always review the current product page and your own pack before use.
This video is for general education and is not medical advice.